• Contact us
  • Advertising Policy
  • Cookie Policy
  • Disclaimer
  • Privacy Policy
  • Terms of Use
Saturday, July 19, 2025
25 °c
Agartala
enewstime
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
    Bumrah should feature in both the remaining Tests: Kumble

    Bumrah should feature in both the remaining Tests: Kumble

    Gill being fired up at Lord’s didn’t have the right effect on his batting returns, says Manjrekar

    Gill being fired up at Lord’s didn’t have the right effect on his batting returns, says Manjrekar

    Jadeja hailed as Team India's MVP after incredible fight at Lord’s

    Jadeja hailed as Team India's MVP after incredible fight at Lord’s

    'Win the toss and bat, put runs on the board': Kaif advises Gill to follow Kohli’s approach  

    'Win the toss and bat, put runs on the board': Kaif advises Gill to follow Kohli’s approach  

    Arsenal sign Olivia Smith for world-record women's transfer fee

    Arsenal sign Olivia Smith for world-record women's transfer fee

    When we played on gravel pitches in Brazil, I'd imagine playing for United: Matheus Cunha

    When we played on gravel pitches in Brazil, I'd imagine playing for United: Matheus Cunha

    I knew with calm and composed approch we can pull off the chase: Deepti Sharma

    I knew with calm and composed approch we can pull off the chase: Deepti Sharma

    'Aussie Ashes line-up is going to be like it is right now', opines Ponting

    'Aussie Ashes line-up is going to be like it is right now', opines Ponting

    Jitesh Sharma to represent Baroda in 2025/26 domestic season after leaving Vidarbha

    Jitesh Sharma to represent Baroda in 2025/26 domestic season after leaving Vidarbha

  • Business
  • Entertainment
  • Health
  • Features
  • TendersNew
No Result
View All Result
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
    Bumrah should feature in both the remaining Tests: Kumble

    Bumrah should feature in both the remaining Tests: Kumble

    Gill being fired up at Lord’s didn’t have the right effect on his batting returns, says Manjrekar

    Gill being fired up at Lord’s didn’t have the right effect on his batting returns, says Manjrekar

    Jadeja hailed as Team India's MVP after incredible fight at Lord’s

    Jadeja hailed as Team India's MVP after incredible fight at Lord’s

    'Win the toss and bat, put runs on the board': Kaif advises Gill to follow Kohli’s approach  

    'Win the toss and bat, put runs on the board': Kaif advises Gill to follow Kohli’s approach  

    Arsenal sign Olivia Smith for world-record women's transfer fee

    Arsenal sign Olivia Smith for world-record women's transfer fee

    When we played on gravel pitches in Brazil, I'd imagine playing for United: Matheus Cunha

    When we played on gravel pitches in Brazil, I'd imagine playing for United: Matheus Cunha

    I knew with calm and composed approch we can pull off the chase: Deepti Sharma

    I knew with calm and composed approch we can pull off the chase: Deepti Sharma

    'Aussie Ashes line-up is going to be like it is right now', opines Ponting

    'Aussie Ashes line-up is going to be like it is right now', opines Ponting

    Jitesh Sharma to represent Baroda in 2025/26 domestic season after leaving Vidarbha

    Jitesh Sharma to represent Baroda in 2025/26 domestic season after leaving Vidarbha

  • Business
  • Entertainment
  • Health
  • Features
  • TendersNew
No Result
View All Result
enewstime
  • Home
  • News
  • Sports
  • Business
  • Entertainment
  • Health
  • Features
  • Tenders
Home Health

How Covid variants escape cellular immune response

ENEWSTIME Desk by ENEWSTIME Desk
February 13, 2022
in Health
30
VIEWS
Share on FacebookShare on Twitter

London, Feb 13 (IANS) A team of Spanish researchers have identified a number of existing strains of SARS-CoV-2, as well as future variants, which have the potential to escape the immune system’s cytotoxic T cell response in some portion of the population.

The T cell response in humans is genetically encoded by HLA molecules — this means different individuals have different HLAs, programmed to recognise invading pathogens based on different parts, or “epitopes” of the pathogens.

While experimental evaluation of the immune response of every human HLA allele to every viral variant is not feasible, the team from Carlos III Health Institute, Spain, turned to computational methods.

The researchers first determined the full set of epitopes from an original reference strain of SARS-CoV-2 from Wuhan, China.

The team discovered 1,222 epitopes of SARS-CoV-2 that were associated with major HLA subtypes, covering about 90 per cent of the human population; at least nine out of every 10 people can launch a T cell response to Covid-19 based on these 1,222 epitopes.

Then, the researchers computationally analysed whether any of 118,000 different SARS-CoV-2 isolates from around the world, described in a National Center for Biotechnology Information (NCBI) dataset, had mutations in these epitopes.

About 47 per cent of the epitopes, they showed, were mutated in at least one existing isolate.

In some cases, existing isolates had mutations in multiple epitope regions, but cumulative mutations never affected more than 15 per cent of epitopes for any given HLA allele type.

When the team analysed susceptible alleles and the geographic origin of their respective escape isolates, the team found that they co-existed in some geographical regions — including sub-Saharan Africa and East and Southeast Asia –, suggesting potential genetic pressure on the cytotoxic T cell response in these areas.

“The accumulation of these changes in independent isolates is still too low to threaten the global human population,” said Antonio Martin-Galiano from the Institute, in the study published in PLOS Computational Biology journal.

“Our protocol has identified mutations that may be relevant for specific populations and warrant deeper surveillance.”

However, Martin-Galiano notes that “unnoticed SARS-CoV-2 mutations” might in future “threaten the cytotoxic T response in human subpopulations”.

Related Posts

Twin studies report global rise in gastrointestinal cancers among middle-aged adults
Health

Twin studies report global rise in gastrointestinal cancers among middle-aged adults

July 18, 2025
Vietnam issues directive to curb African swine fever outbreaks
Health

Vietnam issues directive to curb African swine fever outbreaks

July 18, 2025
Explained: What is 'chronic venous insufficiency' that Donald Trump is suffering from
Health

Explained: What is 'chronic venous insufficiency' that Donald Trump is suffering from

July 18, 2025
South Africa rolls out mpox vaccination programme to curb spread
Health

South Africa rolls out mpox vaccination programme to curb spread

July 18, 2025
Climate, wildlife key predictors of bird flu outbreaks in Europe: Study
Health

Climate, wildlife key predictors of bird flu outbreaks in Europe: Study

July 18, 2025
Gene essential for vitamin D absorption may boost cancer treatment
Health

Gene essential for vitamin D absorption may boost cancer treatment

July 18, 2025
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
D-2050 D-2050 D-2050
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT

About us

Enewstime.in is run by an individual – a Journalist by profession of Tripura with the active help of several journos including senior journalists of the State. On top of that, Enewstime.in being a subscriber of IANS news agency, we have plenty of multi-choice topics to offer to our esteemed readers. Enewstime.in is a venture reach global audience from a tiny State Tripura.

Latest News

Twin studies report global rise in gastrointestinal cancers among middle-aged adults

Vietnam issues directive to curb African swine fever outbreaks

Kaveri Kapur opens up about her battle with PCOS & Uranium Poisoning; Admits 'Feeling better now'

Indian stock market ends lower amid selling in banking, IT sectors

Bumrah should feature in both the remaining Tests: Kumble

Explained: What is 'chronic venous insufficiency' that Donald Trump is suffering from

Contact us

19, Old Thana Road. Banamalipur. PO. Agartala. Pin code 799001. Tripura (West), India.

Email: enewstime2017@gmail.com

Wa: 8794548041

  • Contact us
  • Advertising Policy
  • Cookie Policy
  • Disclaimer
  • Privacy Policy
  • Terms of Use

© 2025 Designed & Developed with ❤️ by Provibe Media LLP

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
  • Business
  • Entertainment
  • Health
  • Features
  • Tenders

© 2025 Designed & Developed with ❤️ by Provibe Media LLP