• Contact us
  • Advertising Policy
  • Cookie Policy
  • Disclaimer
  • Privacy Policy
  • Terms of Use
Tuesday, July 8, 2025
26 °c
Agartala
enewstime
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
    Shadab Khan, Haris Rauf to miss Bangladesh T20Is due to injuries

    Shadab Khan, Haris Rauf to miss Bangladesh T20Is due to injuries

    Paolini announces split with coach Marc Lopez after Wimbledon exit

    Paolini announces split with coach Marc Lopez after Wimbledon exit

    You've got to play him: Anderson urges England to bring Archer for Lord's Test

    You've got to play him: Anderson urges England to bring Archer for Lord's Test

    Olympic champion Nathan Hales registers for SLI, says 'privilege to be part of something new and ambitious'

    Olympic champion Nathan Hales registers for SLI, says 'privilege to be part of something new and ambitious'

    England were back to old ways after doing 'Bazball with brains' in Leeds: Vaughan

    England were back to old ways after doing 'Bazball with brains' in Leeds: Vaughan

    ICC appoints Sanjog Gupta as its new CEO

    ICC appoints Sanjog Gupta as its new CEO

    'I did think we declared late… but India won that's important': Dilip Vengsarkar

    'I did think we declared late… but India won that's important': Dilip Vengsarkar

    Shubman Shines, Akash Roars against England: India Breach Edgbaston Fortress

    Shubman Shines, Akash Roars against England: India Breach Edgbaston Fortress

    2nd Test: Start of day five play delayed due to heavy rain at Edgbaston

    2nd Test: Start of day five play delayed due to heavy rain at Edgbaston

  • Business
  • Entertainment
  • Health
  • Features
  • TendersNew
No Result
View All Result
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
    Shadab Khan, Haris Rauf to miss Bangladesh T20Is due to injuries

    Shadab Khan, Haris Rauf to miss Bangladesh T20Is due to injuries

    Paolini announces split with coach Marc Lopez after Wimbledon exit

    Paolini announces split with coach Marc Lopez after Wimbledon exit

    You've got to play him: Anderson urges England to bring Archer for Lord's Test

    You've got to play him: Anderson urges England to bring Archer for Lord's Test

    Olympic champion Nathan Hales registers for SLI, says 'privilege to be part of something new and ambitious'

    Olympic champion Nathan Hales registers for SLI, says 'privilege to be part of something new and ambitious'

    England were back to old ways after doing 'Bazball with brains' in Leeds: Vaughan

    England were back to old ways after doing 'Bazball with brains' in Leeds: Vaughan

    ICC appoints Sanjog Gupta as its new CEO

    ICC appoints Sanjog Gupta as its new CEO

    'I did think we declared late… but India won that's important': Dilip Vengsarkar

    'I did think we declared late… but India won that's important': Dilip Vengsarkar

    Shubman Shines, Akash Roars against England: India Breach Edgbaston Fortress

    Shubman Shines, Akash Roars against England: India Breach Edgbaston Fortress

    2nd Test: Start of day five play delayed due to heavy rain at Edgbaston

    2nd Test: Start of day five play delayed due to heavy rain at Edgbaston

  • Business
  • Entertainment
  • Health
  • Features
  • TendersNew
No Result
View All Result
enewstime
  • Home
  • News
  • Sports
  • Business
  • Entertainment
  • Health
  • Features
  • Tenders
Home Health

New nasal monoclonal antibody therapy effective against Covid variants, MERS

ENEWSTIME Desk by ENEWSTIME Desk
July 24, 2022
in Health
30
VIEWS
Share on FacebookShare on Twitter

Researchers have discovered a neutralising monoclonal antibody that potentially acts as a potent universal coronavirus therapy against SARS-CoV-2 and all its variants of concern, including Beta, Gamma, Delta, Epsilon and Omicron.

It showed effectiveness against the deadly previous coronaviruses SARS-CoV, that emerged in China in 2002, and MERS-CoV, the Middle East Respiratory Syndrome that appeared in Saudi Arabia in 2012.

It even showed effectiveness against several common cold coronaviruses, according to the study published in the journal PLOS Pathogens.

The monoclonal antibody — 1249A8 hmAb — targets the S2 stalk region of the viral spike (S) protein that is highly conserved among beta-coronaviruses, yet is also essential for the virus to attach and enter cells, leading to infection.

When given as an intraperitoneal injection or a nasal dose, it protected mice from SARS-CoV-2 illness, as measured by maintenance of body weight and clearance of virus from mouse lungs four days after infection, said the team from University of Alabama at Birmingham

“New Covid variants pose the risk of evading the immune system a” even in vaccinated and previously infected individuals, and there remains the potential for other genetically distinct coronaviruses to emerge as new pandemic strains in the future,” said James J. Kobie, from the varsity.

“For these reasons, finding new therapeutic and prophylactic drugs and vaccine strategies that have universal activity against the coronavirus is essential for protecting humanity against the current and future beta-coronavirus outbreaks or pandemics,” he added.

Vaccines and other monoclonal antibodies against SARS-CoV-2 have largely focused on the receptor-binding domain, or the RBD, located at the heads of the S viral protein spike that projects from the surface of the virus.

The RBD is very good at eliciting an immune response, but that portion of the S permits many mutations that can let the virus escape antibodies.

This the team focussed on finding an antibody target on a part of the spike called the S2, or the stalk region. This region is highly conserved and only rarely mutates because that would disrupt its essential function.

After the RBD at the head of the S attaches the coronavirus to a receptor molecule on the surface of a target cell, the S2 stalk acts to bring the virus inside the target cell. There the virus replicates, killing the cell and releasing a hoard of new, infectious virions.

The team screened blood samples from adult convalescent patients.

Seventeen hmAbs showed binding to the S2 protein. Only four of these were able to neutralise a SARS-CoV-2 pseudovirus and a live SARS-CoV-2, including the Beta and Omicron variants.

The top performer, the 1249A8 hmAb, had the broadest and most potent neutralising activity, against strains.

The team had previously demonstrated that direct respiratory delivery of a SARS-CoV-2 RBD-specific 1213H7 hmAb enables substantial dose-sparing therapeutic activity in hamsters.

The 1249A8, 1213H7 cocktail — given as a nasal dose, 12 hours after infections with SARS-CoV-2 Delta or the first SARS-CoV isolated in 2002 — showed broad therapeutic activity in hamsters.

The two hmAbs are being developed as a therapeutic cocktail for Covid-19 by Aridis Pharmaceuticals, a US biopharmaceutical company in its AR-701 cocktail designed for inhaled delivery.

Related Posts

‘No Palm Oil’ label a marketing gimmick, not a health fact: IFBA
Health

‘No Palm Oil’ label a marketing gimmick, not a health fact: IFBA

July 8, 2025
BRICS summit: India used AI to make health systems, climate efforts more effective, says PM Modi
Health

BRICS summit: India used AI to make health systems, climate efforts more effective, says PM Modi

July 8, 2025
Jodhpur AIIMS shares health update on Ashwini Vaishnaw’s father
Health

Jodhpur AIIMS shares health update on Ashwini Vaishnaw’s father

July 8, 2025
No impact of Covid vaccines on sudden deaths & heart attacks, says Karnataka Health Minister
Health

No impact of Covid vaccines on sudden deaths & heart attacks, says Karnataka Health Minister

July 8, 2025
Kerala Minister's hospital remarks creates a flutter as demands for Health Minister's resignation continue
Health

Kerala Minister's hospital remarks creates a flutter as demands for Health Minister's resignation continue

July 8, 2025
Major Rohit Bachwala gets Chief of Army Staff Commendation Card for helping woman deliver baby at rly stn
Health

Major Rohit Bachwala gets Chief of Army Staff Commendation Card for helping woman deliver baby at rly stn

July 8, 2025
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT
D-2050 D-2050 D-2050
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT

About us

Enewstime.in is run by an individual – a Journalist by profession of Tripura with the active help of several journos including senior journalists of the State. On top of that, Enewstime.in being a subscriber of IANS news agency, we have plenty of multi-choice topics to offer to our esteemed readers. Enewstime.in is a venture reach global audience from a tiny State Tripura.

Latest News

Renaming Agartala Town Hall: ‘Was renaming necessary, at all?’

‘No Palm Oil’ label a marketing gimmick, not a health fact: IFBA

BRICS summit: India used AI to make health systems, climate efforts more effective, says PM Modi

Baahubali producer Shobu Yarlagadda recalls tension he experienced prior to film's release!

Indian IT sector to witness soft growth in Q1 despite seasonal strength: Report

Shadab Khan, Haris Rauf to miss Bangladesh T20Is due to injuries

Contact us

19, Old Thana Road. Banamalipur. PO. Agartala. Pin code 799001. Tripura (West), India.

Email: enewstime2017@gmail.com

Wa: 8794548041

  • Contact us
  • Advertising Policy
  • Cookie Policy
  • Disclaimer
  • Privacy Policy
  • Terms of Use

© 2025 Designed & Developed with ❤️ by Provibe Media LLP

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Home
  • News
    • Northeast
    • National
    • International
    • Tripura News
  • Sports
  • Business
  • Entertainment
  • Health
  • Features
  • Tenders

© 2025 Designed & Developed with ❤️ by Provibe Media LLP